武汉市孕妇脱氧雪腐镰孢霉烯醇暴露及健康风险评估
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(1.华中科技大学同济医学院公共卫生学院流行病与卫生统计学系,湖北 武汉 430030;2.华中科技大学同济医学院公共卫生学院营养与食品卫生学系,湖北 武汉 430030)

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闫贻忠 男 讲师 研究方向为食品安全风险评估 E-mail: erniu19880215@sina.com 魏 晟 男 教授 研究方向为食品安全风险评估 E-mail: shengwei@hust.edu.cn

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国家重点研究发展计划(2018YFC1603105)


Exposure and health risk assessment of deoxynivalenol among pregnant women in Wuhan
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(1.Department of Epidemiology and Health Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei Wuhan 430030, China;2.Department of Nutrition and Food Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei Wuhan 430030, China)

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    摘要:

    目的 脱氧雪腐镰孢霉烯醇(DON)是一种食物中常见的真菌毒素,可造成多种健康危害。孕妇作为各种污染物暴露危害的易感人群,目前关于我国孕妇DON暴露水平及其健康风险的证据有限。本研究通过检测武汉市孕妇尿DON水平并估计其食物来源DON的摄入量,为评估我国孕妇DON暴露风险提供参考依据。方法研究对象来自我国湖北省武汉市“同济出生队列”中的103名孕妇,收集其孕期尿液样本,并使用食物频率问卷(FFQ)进行膳食调查。尿DON水平采用超高效液相色谱-串联质谱法(UPLC-MS/MS)测定。结果 103份孕妇尿样中,95份(92.23%,95/103)检出总DON,76份(73.79%,76/103)检出游离DON。孕妇孕期尿中平均总DON水平为19.12 ng/mg creatinine,其中孕早期为15.17 ng/mg creatinine,孕中期为20.91 ng/mg creatinine。孕妇食物来源DON摄入量为0.45~0.89 μg/(kg b.w.·d)。11.65%~22.33%孕妇的食物来源DON摄入量超出了其暂定最大每日耐受摄入量(PMTDI)范围。孕妇饮食中大米及其制品的摄入量与其尿DON水平呈正相关。结论 本研究中武汉市孕妇尿DON水平较低,但检出率较高。今后应关注孕妇DON的暴露水平及其对母亲和胎儿的潜在健康风险。

    Abstract:

    Objective As one of the common mycotoxins in the food, deoxynivalenol (DON) poses multiple health risks. Limited information is available on DON exposure in Chinese pregnant women who they are vulnerable to various pollutants exposure hazards. The purpose of this study was to detect urine DON concentrations and estimate dietary DON intake in Chinese pregnant women, and provide evidence for assessing the risk of dietary DON exposure for pregnant women. Methods The study involved 103 pregnant women from the Tongji birth cohort study in Wuhan, China. Urine samples were collected and dietary investigation was conducted using food-frequency questionnaire (FFQ). The level of DON in urine was determined by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Results Among 103 pregnant women, total DON was detected in 95 urine samples (92.23%,95/103), free DON was detected in 76 samples (73.79%,76/103). The mean total DON levels were 19.12 ng/mg creatinine for both trimesters, 15.17 ng/mg creatinine for the first trimester and 20.91 ng/mg creatinine for the second trimester. The dietary DON intake for pregnant women was 0.45-0.89 μg/(kg b.w.·d). The dietary DON intake of 11.65%-22.33% pregnant women exceeded current guidance regarding the provisional maximum tolerable daily intake (PMTDI) for DON. The diet of pregnant women was mainly rice and its products, and its intake was positively correlated with the concentration of DON. Conclusion In this study, the detection rate of DON in the urine samples of pregnant women in Wuhan was high, but the level of DON was low. Future attention should be paid to the exposure level of pregnant women to DON and the potential health risks to both mother and fetus.

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闫贻忠,李雅楠,宋文静,张珍,李依玲,杨雪锋,郝丽萍,魏晟.武汉市孕妇脱氧雪腐镰孢霉烯醇暴露及健康风险评估[J].中国食品卫生杂志,2021,33(5):600-605.

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  • 收稿日期:2020-12-17
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  • 在线发布日期: 2021-10-14
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