To analyze the monitoring results of foodborne diseases in sentinel hospital in northern Nanjing, so as to provide scientific basis for the clinical prevention and treatment.Methods The cases of foodborne diseases from the sentinel hospital were statistically analyzed. The samples collected from patients with foodborne diseases were detected for Norovirus, non-typhoid Salmonella, Shigella, Vibrio parahaemolyticus, Escherichia coli according to national standards. Results Among 583 stool samples, virus counted for 31.75%(110/583), in which 110 strains were Norovirus, and pathogenic bacteria counted for 2.57%(15/583), in which 8 strains were Vibrio parahaemolyticus. There was significant difference in virus detection rate between different quarter(P＜0.05), but there was no significant difference in pathogenic bacteria detection rate between different quarter(P＞0.05). the detection rate of virus and pathogenic bacteria were 31.73% (185/583) and 2.57% (15/583) respectively, and Norovirus and non typhoid Salmonella were the common pathogens. There was a statistically significant difference in the positive rates between different seasons (P＜0.05). The high risk populations were people in 25-44 age groups. The second and the third quarter of the year were the peak period. Meat and meat products accounted for the greatest proportion of suspected food.Conclusion Norovirus was the predominant pathogen causing foodborne disease followed by Rotavirus. Pathogenic bacteria infection was mainly caused by Vibrio parahaemolyticus. It was necessary to strengthen the health education and management, improve the monitoring system of the sentinel hospital, strengthen the active monitoring, and prevent the spread of the disease.