超高效液相色谱-四级杆串联质谱法检测饮用水中双酚A和双酚F及其氯化消毒副产物
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(1. 首都医科大学公共卫生学院,北京 100069;2.北京市疾病预防控制中心 食物中毒诊断溯源技术北京市重点实验室,北京 100013)

作者简介:

郑赛 女 硕士生 研究方向为食品安全监测 E-mail:zhengsaihxioaen@163.com通信作者:┣┣(中)通信作者┫┫邵兵 男 研究员 研究方向为化学污染监测 E-mail:shaobingch@sina.com

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基金项目:

首都卫生发展科研专项项目(2014-1-3011);北京市优秀人才培养资助(2015000021469G185)


Simultaneous determination of bisphenol A, bisphenol F and their chlorinated byproducts in drinking water by ultra-performance liquid chromatography-tandem mass spectrometry
Author:
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(1.School of Public Health,Capital Medical University,Beijing 100069,China;2.Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning,Beijing Center for Disease Prevention and Control,Beijing 100013,China)

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    摘要:

    建立饮用水中双酚A(BPA)、双酚F(BPF)及其9种氯化消毒副产物的超高效液相色谱-四级杆串联质谱(UPLC-MS/MS)检测方法。方法 500 ml饮用水样品经PLEXA固相萃取柱富集净化后,通过BEH C18色谱柱(2.1 mm×100 mm,1.7 μm)分离,以乙腈-水作为流动相梯度洗脱,采用四极杆串联质谱仪电喷雾负离子模式进行检测,外标法定量。结果 11种目标物质在给定的浓度范围内具有良好的线性关系(r2>0.99),方法定量限(LOQ)为0.01~4.00 ng/L,加标回收率为78.8%~99.6%,相对标准偏差(RSD)均小于12.2%。利用该方法分析40份实际饮用水样品,BPA、BPF和四氯双酚A(4Cl-BPA)3种目标物质在样品中的检出率分别为45.0%(18/40)、40.0%(16/40)和32.5%(13/40),检出浓度分别为0.60~9.40、<LOQ~106.20和<LOQ~0.02 ng/L。结论 本方法具有良好的灵敏度、回收率和重复性,适合饮用水样品中BPA、BPF及其氯化消毒副产物的测定。

    Abstract:

    A analytical method was developed to determine bisphenol A(BPA), bisphenol F(BPF)and their chlorinated products in drinking water using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).Methods Water samples were concentrated and purified with PLEXA solid-phase extraction catridges. The target analytes were separated on a BEH C18 column(2.1 mm×100 mm,1.7 μm)with gradient elution using acetonitrile and water, and identified under negative electrospray ionization. The matrix-matched standard calibration curves were used for the quantitative analysis. Results Good linearities were achieved for all analytes with correlation coefficient (r2) above 0.99. The quantitation limits of the method (LOQ) were in the ranges of 0.01-4.00 ng/L. The recoveries of the target analytes ranged from 78.8%-99.6%, with relative standard deviations (RSD) less than 12.2%. Forty drinking water samples were analyzed by the developed method, and the detection rate of BPA, BPF and 4Cl-BPA were 45.0%(18/40),40.0%(16/40)and 32.5%(13/40), the concentrations were 0.60-9.40 ng/L, <LOQ-106.20 ng/L and

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郑赛,杨蕴嘉,张昕,牛宇敏,王彬,邵兵.超高效液相色谱-四级杆串联质谱法检测饮用水中双酚A和双酚F及其氯化消毒副产物[J].中国食品卫生杂志,2017,29(2):155-159.

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  • 收稿日期:2017-03-01
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  • 在线发布日期: 2017-05-03
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