Studies were carried out to assess the regulation effects of Imedeen on epidermal water and oil content. The results indicated statistically significantly (P<0.01) improvements in skin condition in Imedeen group. And the differences between the Imedeen group and the control group for testing parameters were statistically significant (P<0.05). No adverse effects were observed objectively and subjectively. Author's address Institute of Food Safety Control and Inspection, Ministry of the Public Health of PRC,100021 PRC.