广东省沿海常见海水鱼中多不饱和脂肪酸及其与甲基汞共摄入对神经发育的风险-获益评估
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(1.广东省疾病预防控制中心广东省公共卫生研究院,广东 广州 511430;2.广东省疾病预防控制 中心,广东 广州 511430;3.南方医科大学食物安全与健康研究中心 广东省热带病研究重点实验室, 广东 广州 510515)

作者简介:

黄芮 女 主管医师 研究方向为食品安全风险评估 E-mail:huangr@gdiph.org.cn通信作者:┣┣(中)通信作者┫┫杨杏芬 女 教授 研究方向为食品安全风险评估 E-mail:yangxingfen@21cn.com

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基金项目:

国家重点研发计划(2018YFC1603101);广东省自然科学基金项目(2018A030313230)


Risk-benefit assessment of polyunsaturated fatty acid and methyl mercury on neurodevelopmental effect resulting from consumption of marine fish from coastal areas of Guangdong Province
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(1.Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention,Guangdong Guangzhou 511430, China;2.Guangdong Provincial Center for Disease Control and Prevention, Guangdong Guangzhou 511430, China;3.Guangdong Provincial Key Laboratory of Tropical Disease Research, Food Safety and Health Research Center, Southern Medical University,Guangdong Guangzhou 510515,China)

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    摘要:

    目的 分析广东省沿海常见海水鱼的脂肪酸含量和甲基汞(MeHg)污染水平,定量评估摄入海水鱼对神经发育的风险-获益,为广东省海水鱼的膳食指导提供科学依据。方法 在广东省沿海地区采集20种常见海水鱼样品(共174尾),检测各种脂肪酸和MeHg的含量,并采用联合国粮食与农业组织/世界卫生组织(FAO/WHO)提出的以智力商数(IQ)值为健康终点的风险-获益定量评估模型,评估海水鱼对神经发育的净健康效应。结果 20种海水鱼总脂肪酸含量均值为0.73~19.95 g/100 g,多不饱和脂肪酸(PUFA)为0.18~5.82 g/100 g,总n-3 PUFA为135.69~2 232.74 mg/100 g,二十二碳六烯酸(DHA)为73.61~1 334.00 mg/100 g,二十碳五烯酸(EPA)为43.76~945.67 mg/100 g,所有海水鱼样品的MeHg含量均未超过GB 2762—2017《食品安全国家标准 食品中污染物限量》。基于广东省居民海水鱼消费量均值(100 g/周)、P97.5消费量(830 g/周)、推荐消费量(280 g/周)三种消费模式食用不同鱼种的IQ值净效应为0.5~5.7、3.8~5.6和1.3~5.7,仅在830 g/周的极端消费水平下摄入海鳗带来的MeHg暴露量超过了暂定每周耐受摄入量(PTWI,1.6 μg/kg BW)。结论 按中国居民膳食指南的推荐量消费广东省沿海常见海水鱼,均能对新生儿和婴幼儿带来一定的IQ值净增长效应,但对MeHg含量相对较高的鱼种(如海鳗)需注意食用频率不宜过大。

    Abstract:

    Objective To survey the fatty acids and methyl mercury (MeHg) of marine fish from coastal areas of Guangdong Province and conduct risk-benefit assessment of neurodevelopmental effect, providing scientific basis for dietary instruction of marine fish from Guangdong Province. Methods The fatty acids and MeHg contents were detected in 20 species of marine fish samples collected from coastal areas of Guangdong Province. A quantitative risk-benefit assessment model with a measured value of intelligence quotient(IQ) points, proposed by Food and Agriculture Organization/World Health Organization(FAO/WHO), was performed to assess the net neurodevelopmental effect. Results The average content of total lipids for 20 species of marine fish ranged from 0.73 to 19.95 g/100 g. The content of ploy unsaturated fatty acid (PUFA) ranged from 0.18 to 5.82 g/100 g, the n-3 PUFA ranged from 135.69 to 2 232.74 mg/100 g, the docosahexaenoic acid(DHA) ranged from 73.61 to 1 334.00 mg/100 g, and eicosapentaenoic acid(EPA) varied between 43.76 and 945.67 mg/100 g. The MeHg content in all the fish samples did not exceed the GB 2762-2017 China National Food Safety Standard in this study. Three types of marine fish consumption were used in modeling. It was calculated by the mean intake(100 g/week), P97.5 intake(830 g/week)among Guangdong residents and recommended intake of aquatic products (280 g/week) for the consumption level of marine fish, respectively, and the corresponding net IQ point improvements were 0.5-5.7,3.8-5.6 and 1.3-5.7. Among these fish species, only human exposure to MeHg via consumption of Muraenesoxcinereus Trichiuruslepturus at the extreme consumption level of 830 g/week exceeded the provisional weekly intake tolerance(PTWI, 1.6 μg/kg BW). Conclusion According to the recommended intake of Chinese dietary guidelines, intake of marine fish widespread consumed in coastal areas of Guangdong Province could bring positive neurodevelopmental effects to newborns or infants, while the consumption rate should be lower for fishes with high content of MeHg (such as Muraenesoxcinereus).

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黄芮,陈少威,陈子慧,彭接文,王萍,霍伟伦,黄伟雄,杨杏芬.广东省沿海常见海水鱼中多不饱和脂肪酸及其与甲基汞共摄入对神经发育的风险-获益评估[J].中国食品卫生杂志,2019,31(3):199-204.

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  • 收稿日期:2019-03-14
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  • 在线发布日期: 2019-07-09
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