The trehalose's protective effects on the thermal stability of monoclonal antibody were studied.The results showed that thehalose can serve as a natural protection to increase the thermal stability of monoclonal antibody.Comparing the protection efficiency of the three different trehalose's concentration and different store temperature,the conclusion from the study is that the monoclonal antibody of tetrodotoxin can keep one year at 0 250 mol/L trehalose and at room temperature.