Mouse model is widely used in food science,toxicology and other related areas.In order to provide background data on ICR and BalB/c mice,ten immunological parameters were tested on 60 ICR mice and 60 BalB/c mice according to national standard method for evalution on health food.The results showed significant difference in delayed type hypersensitivity (DTH),antibody integral of sero hemolysin,phagocytosis percentage of murine peritoneal macrophage and natural killer cell activity.It suggests that BalB/c mice is better in researches using the above four parameters.In spleen-body weight ratio,transfer ability of lymphocyte by ConA stimulation,clearance index of charcoal particles and phagocytosis index,no significant difference was shown,suggesting that ICR mice can be appropriate alternative for BalB/c mice in such tests.In addition,ICR mice showed higher sensitivity in thymus-body weight ratio and PFC.The underlying mechanism of such phenomena is still unknown,requiring further research.