Objective To understand the situation and harmfulness of food contamination, ensure the food safety and provide the evidence for citizen health. Method The main markets were slected in Shaoguan downtown, sample 18 kinds and 23 items and 599 pieces were slected randomly and were examined for Cadmium, Lead, Fluorine, Sulfur Dioxide, Ponceau 4R, Sunset Yellow, Tartrazine, Benzoidacid, Sorbic Acid, Acesulfamek, saccharin sodium, pesticide residues. 5 kinds and 11 items and 156 pieces were examined for Salmonella, Hmorrhagic Colitis, Listeria monocygenes, Vibrio parahamolyticus. Results In samples of vegetable, the detection rates of Methamidophos were 6.07 % and the detection rates of Dichlorvos were 8.41 %. The rates over standard for Cadmium, Lead, Sulfur Dioxide were 14.7%, 20.6%, 4.4% respectively. The percentages of Fluorine were relatively high in tea, the average data were 106. lmg/kg. The qualification rate of the contents of Benzoic acid, Sorbic Acid in food were 100%. The detection rates in food of Vibrio parahamolyticus were 20.0%, .and Salmonella were 5.0%. Conclusion Some of the food products in Shaoguan downtown could be contaminated by Cadmium, Lead, Fluorine, pesticide residues, foodborne pathogenic.