Objective To investigate and control a large scale food poisoning in a university of Guangzhou city, Method The informations were collected from epidemiologieal surrey, hygienic investigation and laboratory test and were analyzed with SPSS 11.0. Results 206 patients from 3 universities were suffered from the gastrointestinal infection symptom such as fever, diarrhea, bellyache, etc. Epidemiologieal survey indicated that there were two incidental pinnacles. The central tendency of class and dormitory distribution, and the specific age tendency were not observed. The case control study indicated that the No. 2 refectory in the university was the exposure location. Baiqie chicken could be the high risk food. Salmonella enteritidis were found in the food, cook tools and the anal cotton swabs of the patients and cooks. Conclusion The report indicated that the food poisoning outbreak may be caused by Salmonella e nteritidis.