The safety assessment were carried out with developmental toxicity evaluation model applied to high throughput screening in large scale in vitro, which could avoid the shortcomings of human and animal experiments. In the current evaluation models, the embryonic stem cell test(EST), the whole embryo culture(WEC) and the micro mass culture(MM) were widely approved and recommended because they could have the high prediction values between in vitro and vivo tests. The development and advance of screening tests ...