Objective To establish a method for the detection of lead in wine by using iridium (Ir) as a permanent chemical modifier for electro-thermal atomic absorption spectrometry (ETAAS) . Method Using iridium (Ir) as a permanent chemical modifier coated on the integrated platform of transversely heated graphite atomizer (THGA). Pyrolysis temperature, atomization temperature and analysis performances were estimated. Results With the use of Ir, the RSDs (n=5) were in the range of 0.3%～2.8% and the recoveries were in the range of 95.7%～104.6%. Detection limit for lead was 0.4μgL-1, the characteristic mass was 30 pg. Conclusion This method was accurate, simple and sensitive, and met the demands for analyzing trace elements.