Abstract:In order to investigate a management system for safely utilizing puffer fish resources, a series of management measures regarding the cultivation, processing, sale and handling of aquaculture puffer fish were conducted under the support of Ministry of Health and Ministry of Science and Technology. No food poison accident has been reported during millions of eating trials in the pilot study. All documents developed by the study group could provide references for setting up management measures on taking puffer fish as a novel food source in China.