Objective To assess bovine colostrums(BC) safety by reproduction study by observe the influence of BC on reproductive development.Methods Forty four-week-old Spraque-Dawley rats(20 male and 20 female) were randomly divided into BC group and control group according to their body mass and were fed with the diet with 10% BC and normal diet,respectively.These indexes of parental generation were examined,such as body weight,daily food intakes,estrous cycle,fertility index,pregnant index,gestation length,number of pups,blood hormone level,reproduction organ and sperm parameters.Sex ratio,anogenital distance,vaginal opening(VO),preputial separation(PPS) were also reported.Results The weight of left seminal vesicle was slightly lower in bovine colostrums group than that in control group(P<0.05),while BC significantly increased the total number of sperms(P<0.05).BC diet vs control diet significantly decreased the level of luteinizing hormone(LH),prolactin(PRL) and progesterone(P) in female rats of the P generation(P<0.05).And the level of LH in male rats of the P generation was Lower than that of control group(P<0.05).There was no significant differences on the other indices such as estrous cycle,mating index,fertility index,pregnant index,gestation length,Number of pups,sex ratio,anogenital distance,vaginal opening(VO),preputial separation(PPS) between Bovine colostrums group and control group.Conclusion Bovine colostrums did not show significant influence on the reproductive development ability in the one-generation reproduction study.But there are changes in seminal vesicle,the total number of sperms and the level of hormones of parental rats.Further study is required to determine whether Bovine colostrums have adverse effects on reproductive health for F2-generation.