Objective Developing an optimized method to remove nitrite in marine products (dried prawns) by saline immersion treatment. Methods After the determination of nitrite content by spectrophotometric, the effect of nitrite reduction was studied through orthogonal testing method, and factors including concentration, amount, temperature and immersion time of saline were tested. Results The optimized condition for nitrite reduction is 10.00 g of dried prawns in 100 ml of 0.9 g/L saline, 20 min immersion at room temperature or below. Conclusion The experiment indicated that saline immersion treatment was effective for nitrite reduction, the concentration and amount of saline were the primary factors.