Circumstance and problems of changes of registration in health foods were analyzed to provide basic data for CFDA, and to provide guidance for applicants. MethodsThe quantities and change types etc. of changes registered by SFDA were analyzed from 2009-2012. The reasons of registration refused were summarized. ResultsTotal 445 changes of registration were registered from 2009 to 2012. Mainly types were change of name, specification, property right, guarantee period and quality standard. The common problem of product name was that proposed name is not fit for the regulation related. The primary reason refused was unqualified sample-test and self-test reports.ConclusionCircumstances of changes of registration are mainly related with the market factors. CFDA is suggested to push forward management reform of change of registration timely.