我国成人饮白酒者抗雄激素作用样邻苯二甲酸酯类物质的累积风险评估
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(国家食品安全风险评估中心,北京 100022)

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隋海霞 女 研究员 研究方向为风险评估 E-mail:suihaixia@cfsa.net.cn通讯作者:┣┣(中)通信作者┫┫张磊 男 副研究员 研究方向为风险评估 E-mail:zhl30@126.com

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国家自然科学基金课题(81273081)


Cumulative risk assessment of anti-androgenic phthalate acid esters of adult liquor drinkers in Chinese population
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(China National Center for Food Safety Risk Assessment,Beijing 100022,China)

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    摘要:

    评估中国居民成人饮白酒者(以下简称饮酒者)抗雄激素作用样邻苯二甲酸酯类物质,即邻苯二甲酸二(2-乙基己基)酯(DEHP)、邻苯二甲酸二丁酯(DBP)、邻苯二甲酸丁基苄基酯(BBP)的累积膳食摄入水平及其健康风险。方法 利用2011—2013年间收集的24类食品中DEHP、DBP和BBP含量数据,结合2002年中国居民营养与健康状况调查数据,采用简单分布评估的方法,计算我国居民成人饮酒者全人群以及18~59岁(男、女)、60岁以上(男、女)等4个不同性别-年龄组人群DEHP、DBP和BBP的膳食摄入水平。采用危害指数法计算经膳食联合暴露于DEHP、DBP和BBP的健康风险。结果 单一化学物的风险评估发现,我国成人饮酒者中全人群和各性别-年龄组人群的DEHP、DBP 和BBP的平均摄入量和高食物消费量人群(P97.5)的摄入量均低于其相应的每日可耐受摄入量(TDI)。进一步分析发现,约有0.64%(18/2 800)的个体DBP摄入量超过其TDI。而采用危害指数方法进行的累积风险评估发现,我国成人饮酒者全人群和各性别-年龄组人群的危害指数均低于1;有0.79%(22/2 800)的个体危害指数超过1。结论 中国居民成人饮酒者全人群的抗雄激素作用样PAEs的累积暴露健康风险较低,有24例个体的健康风险需要关注,建议适量饮酒。

    Abstract:

    To assess combined dietary exposure and health risk of anti-androgenic phthalate acid esters(PAEs) , that is,DEHP,DBP and BBP among Chinese adult liquor drinkers, including general drinkers population, male and female adults aged 18-59 years old as well as elderly male and female aged 60 and above.Methods Food samples were collected during 2011-2013 and categorized into 24 food groups which covered major foods in China. Food consumption data were taken from China national nutrition and health survey performed in 2002. Mean concentrations of individual PAEs were combined with individual food consumption data to estimate dietary exposure of DEHP, DBP and BBP respectively. Then, hazard index approach was used to calculate the cumulative risk of anti-androgenic phthalate acid esters. Results It was found that mean and high consumption (P97.5) for the general adult liquor drinkers as well as 4 age-gender groups were well below the corresponding tolerable daily intake (TDI) of DEHP, DBP and BBP respectively. Further analys is showed that there were 18 individuals having intake higher than the TDI of DBP, accounting for 0.64 percentage of Chinese adult liquor drinkers. As for combined exposure for DEHP, DBP and BBP, mean and high consumption consumer hazard index (P97.5) for the general adult liquor drinkers as well as 4 age-gender groups were well below 1. Further analysis showed that there were 22 individuals having hazard index higher than 1, accounting for 0.79 percentage of Chinese adult liquor drinkers.Conclusion It suggested that cumulative risk to anti-androgenic PAEs (DEHP, DBP and BBP) among general Chinese adult liquor drinkers population is low and do not pose an imminent health concern. A greater health risk exists for 22 adult liquor drinkers for whom moderate alcohol consumption is advised.

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隋海霞,王珊,杨大进,刘兆平,张磊.我国成人饮白酒者抗雄激素作用样邻苯二甲酸酯类物质的累积风险评估[J].中国食品卫生杂志,2015,27(4):451-455.

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