Abstract:To analyze the effectof age and gender on egg allergens, and to explore the main epitopes of OM in chinese population.Methods 21 patients diagnosed as egg allergy were included, patients were divided into 3 groups:younger than 1-year-old (group A, 6 subjects), 2 to 3-years-old (group B, 7 subjects), and elder than 3-years-old (group C, 8 subjects). The serum of patients, the specific IgE of ovomuciod, ovalbumin, ovotransferrin and epitopes of ovomuciod were detected by immunodot-blots. Epitopes of ovomuciod were predicted by DNAStar. Results Immunodot-blots analysis showed that the numbers of serum samples which could react with ovomuciod were 2 in group A, 7 in group B and 5 in group C, respectively. All patients samples showed positive to ovalbumin. 3 patients IgE in group A could binding to ovotransferrin,as well as 6 samples in group B and 5 samples in group C.Conclusion Ovomuciod sIgE reactivity to egg allergens differed according to children's age. The DNAStar biological software was used to predict the epitopes of the egg type mucin which was low in Tianyin.
