基于回归和分类树模型的重庆7~17岁儿童青少年高尿酸血症影响因素分析
作者:
作者单位:

1.重庆医科大学公共卫生与管理学院,重庆 400016;2.重庆市疾病预防控制中心,重庆 400042

作者简介:

陈京蓉 女 在读研究生 研究方向为营养与食品卫生 E-mail:598290735@qq.com

通讯作者:

李继斌 男 教授 研究方向为营养与慢性非传染性疾病 E-mail:100091@cqmu.edu.cn

中图分类号:

R155

基金项目:


Analysis on the influencing factors of hyperuricemia among children and adolescents aged 7-17 years in Chongqing: based on regression and classification tree models
Author:
Affiliation:

1.School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China;2.Chongqing Center For Disease Control And Prevention, Chongqing 400042, China

Fund Project:

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    摘要:

    目的 了解儿童青少年高尿酸血症(HUA)的影响因素,为HUA的早期干预提供参考依据。方法 2016—2017年,采用多阶段分层随机抽样方法在重庆市各选取3个城市和农村调查点,抽取部分7~17岁在校学生,开展问卷调查、体格测量和实验室检测,采用因子分析法分析膳食模式,应用回归和分类树模型探索HUA的影响因素。结果 共抽取1 544名学生,HUA发生率为19.49%,男生高于女生,年龄较高的学生的HUA检出率也较高。因子分析共纳入4个公因子,对总方差的贡献率为42.641%,对应肉类蔬果、零食、谷薯豆类坚果和主食4种膳食模式。按照每个因子得分由低到高排序后分成4等分(Q1~Q4),单因素回归结果显示肉类蔬果模式、主食模式Q4水平HUA患病风险分别是Q1水平的1.687倍、1.764倍,谷薯豆类坚果模式Q4水平的患病风险是Q1水平的0.588倍。调整监测地区类型、性别、年龄、腰围、体质指数、血脂、血糖、身体活动等因素后,谷薯豆类坚果模式Q4水平的患病风险是Q1水平的0.638倍。分类树模型显示,年龄、性别、BMI水平是该群体HUA主要的影响因素。结论 重庆市7~17岁儿童青少年HUA检出率较高,应特别关注男生、12岁及以上、超重和肥胖学生HUA的发生,鼓励谷薯豆类坚果膳食模式。

    Abstract:

    Objective To investigate the influencing factors of hyperuricemia (HUA) among children and adolescents, and provide evidences for early intervention.Methods From 2016 to 2017, a multi-stage stratified random sampling method was used to select three urban and rural sites in Chongqing, and some students aged 7~17 years were selected to conduct questionnaires, physical measurements and laboratory tests. Factor analysis was used to analyze dietary patterns. Regression and classification tree models were used to explore the influencing factors of HUA.Results A total of 1 544 students were enrolled in the study. The prevalence rate of HUA was 19.49% which was higher among male and elder students. Four common dietary patterns including meat and vegetable/fruit, snacks, cereal/potato/bean/nut and staple were included in the factor analysis, and the contribution rate to total variance was 42.641%. Scores of each pattern were divided into four ranking (Q1~Q4) from low to high. The results of univariate regression showed that participants with the fourth quartile (Q4) score of meat and vegetable/ fruit pattern had a higher risk of HUA (OR=1.687) compared to those with the first quartile (Q1) score, while the odds ratio was 1.764 in staple pattern; participants with the Q4 score of bean/nut pattern had a lower risk of HUA (OR=0.588) compared to those with Q1 score. After adjusting for confounding factors of monitoring area, gender, age, waist circumference, BMI, blood lipids, blood sugar and physical activity, participants with Q4 score had a lower risk of HUA (OR=0.638)compared to those with Q1 score in cereal/potato and bean/nut pattern. Classification tree model showed that age, gender and BMI level were the main influencing factors of HUA among this group.Conclusion The prevalence of HUA in children and adolescents aged 7~17 years in Chongqing was high. Strong attention should be paid to the incidence of HUA among boys, especially aged 12 years and above, overweight and obese, and the dietary pattern of cereal/potato and bean/nut pattern should be encouraged.

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陈京蓉,罗书全,熊鹰,赵怡楠,李继斌.基于回归和分类树模型的重庆7~17岁儿童青少年高尿酸血症影响因素分析[J].中国食品卫生杂志,2022,34(5):1077-1082.

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  • 收稿日期:2021-04-30
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  • 在线发布日期: 2022-12-01
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