我国食品接触用不锈钢制品中金属元素迁移理论风险评估
作者:
作者单位:

1.国家食品安全风险评估中心,北京 100021;2.北京大学公共卫生学院毒理学系/食品安全毒理学 研究与评价北京市重点实验室,北京 100191

作者简介:

袁悦 女 硕士研究生 研究方向为安全性评价和风险评估 E-mail:2011210121@bjmu.edu.cn

通讯作者:

隋海霞 女 研究员 研究方向为食品安全风险评估 E-mail:suihaixia@cfsa.net.cn

中图分类号:

R155

基金项目:

国家自然科学基金(32061160474)


Theoretical risk assessment of metal elements from stainless-steel products for food contact in China
Author:
Affiliation:

1.China National Center for Food Safety Risk Assessment, Beijing 100021, China;2.Department of Toxicology, School of Public Health, Peking University/Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, China

Fund Project:

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    摘要:

    目的 建立推导食品接触材料来源的危害因素可接受暴露水平的方法,并评估食品接触用不锈钢制品中5种金属元素迁移的理论暴露水平及潜在健康风险,对我国现行标准的适宜性进行评价。方法 参考国际上饮用水中化学污染物、金属制品来源的金属元素,以及食品接触材料来源的污染物可接受暴露水平的分配原则,综合考虑金属元素的膳食暴露水平和毒理学数据,确定我国居民不锈钢制品来源的金属元素的可接受暴露水平。假定每天摄入1 kg由不锈钢制品盛放的食品,利用GB 4806.9—2016《食品安全国家标准 食品接触用金属材料及制品》中规定的不锈钢制品中铅、镉、砷、铬、镍元素的特定迁移限量,估计5种金属元素迁移的理论暴露水平,并依据推导的可接受暴露水平评估不锈钢制品中金属元素迁移的健康风险。结果 食品接触用不锈钢制品中铅、镉、砷、铬和镍的可接受暴露水平分别为0.06(铅儿童)、0.13(铅成人)、0.08、0.30、60.00和2.40 μg/kg·BW。食品接触用不锈钢制品来源的铅和砷的理论暴露水平分别为2.50(铅儿童)、0.83(铅成人)和0.67 μg/kg·BW,暴露限值分别为0.02(铅儿童)、0.16(铅成人)和0.45,远低于1。镉、铬和镍的理论暴露水平分别为0.33、33.33和8.33 μg/kg·BW,分别为相应不锈钢制品来源的可接受暴露水平的400.12%、55.56%和347.22%。结论 在我国现行标准下,根据理论暴露结果,铬元素迁移导致的风险较低,镉、镍、铅和砷迁移导致的健康风险相对较高,建议开展基于实际迁移水平的风险评估,为是否需要修订GB 4806.9—2016提供科学依据。

    Abstract:

    Objective To establish a method to derive the acceptable exposure levels of hazard from food contact materials, and assess the theoretical exposure levels and potential health risks of five metal elements released from stainless-steel products for food contact, so as to evaluate the suitability of the current National Standard of Food Safety in China.Methods The acceptable exposure levels of metal elements from stainless-steel products in China were determined in accordance with international allocation principles for acceptable exposure levels of chemical contaminants from drinking-water, metal elements from metal products, and contaminants from food contact materials, dietary exposure levels and toxicology data for the metal elements were also considered. The specific migration limits of lead, cadmium, arsenic, chromium, and nickel in the “National Standard of Food Safety: Metal Materials and Articles for Food Contact (GB 4806.9—2016)”, were used to theoretically estimate the exposure levels of the five metal elements, assuming that each person consumed 1 kg of food in stainless-steel products per day. The health risks of metal elements in stainless-steel products were assessed based on the derived acceptable exposure levels.Results Acceptable exposure levels for lead from stainless-steel products were 0.06 (children), 0.13 μg/kg·BW (adults), and those for cadmium, arsenic, chromium, and nickel were 0.08, 0.30, 60.00, and 2.40 μg/kg·BW, respectively. The theoretical exposure levels for lead from stainless-steel products for food contact were 2.50 (children) and 0.83 μg/kg·BW (adults) with margins of exposure of 0.02 (children) and 0.16 (adults). Meanwhile for arsenic the theoretical exposure level was 0.67 μg/kg·BW, with an MOE of 0.45. Notably, for lead and arsenic the MOE were lower than 1. The theoretical exposure levels for cadmium, chromium, and nickel were 0.33, 33.33, and 8.33 μg/kg·BW, which were 400.12%, 55.56%, and 347.22% of the acceptable exposure levels, respectively.Conclusion Under the current standards in China, the health risk from the release of chromium was low, whereas the health risks from the release of cadmium, nickel, lead, and arsenic were relatively high. Notably, these standards are based on theoretical exposure rather than experimental data. Therefore, it is recommended that risk assessment be performed based on actual migration levels to provide a more accurate assessment of the health risks. This information could then be used to decide whether to revise the current standards (GB 4806.9—2016).

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袁悦,赵方蕾,杨道远,张泓,高洁,隋海霞,郝卫东.我国食品接触用不锈钢制品中金属元素迁移理论风险评估[J].中国食品卫生杂志,2023,35(5):712-716.

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  • 收稿日期:2022-03-24
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  • 在线发布日期: 2023-08-14
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