栀子食用人群栀子苷暴露评估
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1.湖南农业大学;2.国家食品安全风险评估中心;3.中国中医科学院中药研究所中药质量控制技术国家工程实验室

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Exposure assessment of geniposide in Chinese Gardenia consuming population
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1.Hunan Agricultural University,Hunan 2.Changsha;3.China National Center for Food Safety Risk Assessment,Chinese Academy of Medical Sciences,NHC Key Laborarory of Food Safety Risk Assessment;4.National Engineering Laboratory of Chinese Medicine Quality Control Technology,Institute of Traditional Chinese Medicine,China Academy of Traditional Chinese Medicine

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    摘要:

    目的 了解我国栀子食用情况,评估我国栀子食用人群栀子苷暴露水平及健康风险。 方法 通过文献检索收集我国栀子中栀子苷含量数据,结合2019-2022年我国食药物质消费量调查数据,概率评估全国居民通过食用栀子栀子苷暴露水平及健康风险。结果 我国9省栀子食用率为10.32%,食用量均值为0.41 g/d。简单分布评估显示9省栀子食用人群的栀子苷平均暴露量为0.28 mg/kg?BW,9省中有17.01%的居民栀子苷暴露量超过栀子苷每日可耐受摄入量(tolerable daily intake ,TDI)。河南省食用人群平均暴露量最高,为0.54 mg/kg?BW。概率评估结果显示全国有16.70 %的栀子食用人群栀子苷暴露量超过TDI,具有健康风险。栀子食用量是全国食用人群栀子苷暴露的高敏感因素。结论 我国栀子食用人群的栀子苷暴露风险总体较低,但部分高消费人群(P95)存在健康风险。

    Abstract:

    Objective To understand the situation of Gardenia consumption in China and to assess the geniposide exposure level and health risk of the Gardenia consumption population in China. Methods Data on geniposide content in Gardenia jasminoides in China were collected through literature search, and probabilistically assessed the level of geniposide exposure and health risk of the national population through the consumption of Gardenia jasminoides in China by combining the data from the survey on the consumption of food and drug substances in China from 2019-2022.Results The consumption rate of gardenia in 9 provinces of China was 10.32%, and the mean value of consumption was 0.41 g/d. Simple distribution assessment showed that the mean exposure of geniposide of the edible population of Gardenia in 9 provinces was 0.28 mg/kg?BW, and In 9 provinces, 17.01% of the residents' geniposide exposure exceeded the Gardenia gardenia gardenia glycoside tolerable daily intake (TDI). The average exposure of the edible population in Henan Province was the highest 0.54 mg/kg?BW. The results of the probabilistic assessment showed that 16.70 % of the Gardenia consuming population in the country had health risks from geniposide exposure above TDI,with health risk. The amount of Gardenia consumed by the edible population of Gardenia in China is a high sensitivity factor for geniposide exposure.Conclusion The risk of exposure to geniposide in China's Gardenia consuming population is generally low, but there is a health risk in some high consuming population (P95).

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  • 收稿日期:2024-01-03
  • 最后修改日期:2024-04-07
  • 录用日期:2024-04-08
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