To evaluate the potential risk of cattle hide protein on infants health, its amino acid pattern and contamination indexes were analyzed. Sixty brands of infant milk powder, from markets and households in Fuyang were collected and analuzed by semi-quantitative method. It was found that: 1) In comparison with milk protein, glycine was characteristically increased in cattle hide protein, while essential amino acids were rather low. Its amino acid score was only nineteen based on FAO/WHO recommended infants amino acid pattern (1985). 2) Contamination indexes of toxic metals (Pb, As, Hg, Cd) in hydrolytic cattle hide protein fell in normal range. 3) For the 60 infant milk powder samples, 70% had low protein content, about 40% was adulterated with cattle hide protein, which suggested inferior quality products. The present study showed it was important to strengthen the inspection of food nutrition indexes and set up rapid assay method for detecting adulterated components.