Objective Cadmium content in rice originated from Yangze watershed was analyzed with spatial statistics, which aimed to provide scientific basis for source control of grain cadmium contamination. Methods The spatial auto-correlation indicated the spatial clustering of cadmium contamination. Results The result illustrated the rice planted around Xiang River, Min River, Pei River, Tuo River, Qingyi River and Dadu River hold a higher level of cadmium content than other places. The Moran's I is 0.596 (p with statistical significance), which presented a medium spatial clustering to the rice cadmium contamination. Therefore, Xiang River and Min River watershed presented “high-high” clustering while Yachi River presented a low-low clustering. Conclusion The rice cadmium contamination around Yangze watershed emerged a medium clustering while some areas presented spatial variability.