我国食品接触用不锈钢制品中金属元素迁移的理论风险评估
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1.国家食品安全风险评估中心;2.北京大学公共卫生学院毒理学系/食品安全毒理学研究与评价北京市重点实验室

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Theoretical risk assessment of metal elements from stainless-steel products for food contact in China
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Affiliation:

1.China National Center for Food Safety Risk Assessment;2.Department of Toxicology,School of Public Health,Peking University/Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    目的 建立推导食品接触材料来源的危害因素可接受暴露水平的方法,并评估食品接触用不锈钢制品中5种金属元素迁移的理论暴露水平及潜在健康风险,对我国现行标准的适宜性进行评价。方法 参考国际上饮用水中化学污染物、金属制品来源的金属元素、以及食品接触材料来源的污染物的可接受暴露水平的分配原则,综合考虑金属元素的膳食暴露水平和毒理学数据,确定我国居民不锈钢制品来源的金属元素的可接受暴露水平。假定每天摄入1 kg 由不锈钢制品盛放的食品,利用GB 4806.9-2016《食品安全国家标准 食品接触用金属材料及制品》中规定的不锈钢制品中铅、镉、砷、铬、镍元素的特定迁移限量(SML),估计五种金属元素迁移的理论暴露水平,并依据推导的可接受暴露水平评估不锈钢制品中金属元素迁移的健康风险。结果 食品接触用不锈钢制品中铅、镉、砷、铬和镍的可接受暴露水平分别为0.06(铅儿童)、0.13(铅成人)、0.08、0.30、60和2.40 μg/kg bw。食品接触用不锈钢制品来源的铅和砷的理论暴露水平分别为2.50(铅儿童)、0.83(铅成人)和0.67 μg/kg bw,暴露限值(MOE)分别为0.02(铅儿童)、0.16(铅成人)和0.45,远低于1。镉、铬和镍的理论暴露水平分别为0.33、33.33和8.33 μg/kg bw,分别为相应不锈钢制品来源的可接受暴露水平的400.12%、55.56%和347.22%。结论 在我国现行标准下,根据理论暴露结果,铬元素迁移导致的风险较低,镉、镍、铅和砷迁移导致的健康风险相对较高,建议开展基于实际迁移水平的风险评估,为是否需要修订GB 4806.9-2016提供科学依据。

    Abstract:

    Objective To establish a method to derive the acceptable exposure levels of hazard factors from food contact materials, to assess the theoretical exposure levels and potential health risks of five metal elements released from stainless-steel products for food contact, and to evaluate the suitability of the current National Standard of Food Safety in China. Methods With reference to the international allocation principles of acceptable exposure levels of chemical contaminants from drinking-water, the metal elements from metal products, and the contaminants from food contact materials, the acceptable exposure levels of metal elements from stainless-steel products in China were determined by considering both the dietary exposure levels and the toxicology data of the metal elements. Based on the specific migration limits (SML) of lead, cadmium, arsenic, chromium, and nickel in the National Standard of Food Safety: Metal Materials and Articles for Food Contact (GB 4806.9-2016), the exposure levels of the five metal elements were theoretically estimated, assuming 1 kg food in stainless-steel products was consumed by each person per day. The health risks of metal elements from stainless-steel products were assessed based on the derived acceptable exposure levels. Results Acceptable exposure levels for lead, cadmium, arsenic, chromium, and nickel from stainless-steel products are 0.06 (lead for children), 0.13 (lead for adults), 0.08, 0.30, 60, and 2.40 μg/kg bw, respectively. The theoretical exposure levels for lead and arsenic from stainless-steel products for food contact were 2.5 (lead for children), 0.83 (lead for adults), and 0.67 μg/kg bw, with margins of exposure (MOE) of 0.02 (lead for children), 0.16 (lead for adults), and 0.45, respectively. The theoretical exposure levels for cadmium, chromium, and nickel were 0.33, 33.33, and 8.33 μg/kg bw, which were 400.12%, 55.56%, and 347.22% of the acceptable exposure levels, respectively. Conclusion Under the current standard in China and based on the results of theoretical exposure, the health risk from the release of chromium was low, while the health risks from the release of cadmium, nickel, lead, and arsenic were relatively high. Therefore, it is recommended to perform risk assessment based on the actual migration levels, so as to provide scientific basis for whether or not to revise the current standard (GB 4806.9-2016).

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  • 收稿日期:2022-03-24
  • 最后修改日期:2023-01-17
  • 录用日期:2022-07-18
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