To determine the antibiotic susceptibility of Salmonella isolates from retail chicken and evaluate the spectrum of their multiple antimicrobial resistance , fifty one strains of identified Salmonella isolates were analyzed for minimal inhibitory concentrations (MICs) with 30 kinds of antibiotics using the disk diffusion method All of the strains were resistant to at least three antibiotics. Eight strains (15 7%) were resistant to three kinds, thirteen strains (25 5%) to four, nine strains (17 6%) to five, twelve strains (23 5%) to six to nine and nine strains (17 6%) to ten antimicrobial agents All of the 51 strains were resistent to vancomycin,erythromycin and mezlocillin. Resistance to the following antibiotics was common among isolates: nalidixic acid (52 9%), sulfonamides(35 9%), streptomycin (33 3%), tetracycline (29 4%), ampicillin (23 5%), carbenicillin (21 6%), amoxicillin (19 6%), piperacillin (19 6%), mezlocillin (17 6%), doxycycline (17 6%) and chloramphenicol (13 7%). It is important that one isolate of Salmonella typhimurium isolated from the retail chicken in Fujian province was resistant to fifteen antimicrobial agents, which exhibiting the antimicrobial resistance profile similar to that of Salmonella typhimurium DT104. These data indicate that the fifty one Salmonella isolates recovered from retail raw chicken are commonly resistant to multiple antibiotics.