Objective To understand the epidemiological characteristics of food poisoning events in Guangxi and provide scientific basis for developing prevention and control strategies.Methods Descriptive epidemiological methods were used to analyze the characteristics of food poisoning events from 2005 to 2011 in Guangxi.Results 256 food poisoning events,6099 poisoning cases and 99 fatalities were reported during 2005—2011.Most events(75.39%) were caused by microorganism,toxic plants and animals.The second and third quarters were at the peak during a year when food poisoning events frequently occurred(61.33%).The numbers of reported food poisoning events were significantly different among regions in Guangxi,more from the western and northern and fewer from the eastern and southern.The rural households,schools and catering service units were the main places(78.13%).Conclusion The supervision and management of food safety for school canteens and social catering service units is one key to reduce the food poisoning events in Guangxi,and the other is propaganda and education of food safety in rural areas.