The contaminative status and the sources of organic tin(organotin) compounds in marine environment and its toxicity to marine animal and human were summarized.It has been found that organotin compound can induce imposex in female gastropods,reproductive toxicity and genotoxicity on mammalian cells,and immunotoxicity on human cells in vitro,especially triphenyltin compounds(TPT) and tributyltin compounds(TBT).Organotin compounds were widely used as antifouling paints for boats and other marine buildings,and organotin compounds were accumulated in sea products.The organotin compounds were accumulated in the food chain and inducing hazardous effect on human health.The occurrence of organotin compounds in sea products indicated a potential danger for the health of people consuming seafood.More information is needed to determine the risk of organotin compounds to human health.